ESMO 24: Butterfly Effect? J&J’s Rybrevant Looks Beyond Lung Cancer

New Phase II data for the bispecific antibody show promise in colorectal cancer as the company seeks to spread the bispecific antibody’s wings. Phase III trials are on the horizon, where it will need to go up against standard of care.    

esmo entrance
ESMO 24 in Barcelona, Spain • Source: ESMO

While Johnson & Johnson has been building the case for using Rybrevant in lung cancer at recent medical meetings with updated data from its MARIPOSA trial program, earlier-stage results in colorectal cancer point to another promising, and much bigger, market for the EGFR/MET targeted bispecific.

More from ESMO

ESMO 24: SunRISes On J&J’s TAR-200 In Bladder Cancer

 

J&J acquired Taris in 2019 to gain access to TAR-200 and its drug delivery platform. Now, early clinical data suggest the product could delay or remove the need for cystectomy in several bladder cancer settings and the US healthcare giant is eyeing multi-blockbuster sales.    

ESMO 24: CDK2 Inhibitors - Where Next For The Novel Class?

 

The Barcelona meeting saw early data from two candidates from Incyte and Pfizer which suggest some progress for a new drug mechanism that has so far underwhelmed.    

ESMO 24: Investors Are Starting To Believe In BioNTech’s Cancer Drugs

 

The company’s investment in oncology is starting to pay off, with its PD-L1/VEGF inhibitor BNT324 generating particular interest at ESMO.

ESMO 24: Bayer Prostate Drugs Old And New Deliver On Survival

 
• By 

The German group's goal of expanding Nubeqa into wider prostate cancer patient populations has probably been reached with the results from the Phase III ARANOTE study, while a combination of its older product Xofigo and Pfizer and Astellas’ Xtandi is set to become standard of care for another subset.

More from Conferences

M&A Takeoff May Be Delayed, Experts Predict

 

All the elements for a big M&A year are in place, but political uncertainty and interest rates could push more deals into the second half of the year, according to business development experts at BIO CEO & Investor.

How To Work With Trump, The Future Of US Life Sciences And More: Updates From BIO CEO & Investor

 

Highlights from the BIO CEO & Investor Conference, held in New York 10-11 February, include the impact of US political changes, Chinese companies entering the obesity race, and IPO pitfalls.

BMS Enters A Catalyst-Rich Era Full Of Both LOEs And New Launches

 
• By 

Bristol Myers Squibb has been in a rapid growth phase to make up for upcoming losses of exclusivity. Scrip spoke with executives about further catalysts coming in the next 18-24 months.