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In Silico Drug Design: Finally Ready For Prime Time?

 
• By Michael Goodman

Advances in computational power and in the application of quantum mechanics to drug modeling are rekindling interest in in silico drug design. The prize is a steep reduction in the cost of discovery and an increase in the quality of lead candidates.

Building on improvements in the price-performance of computing power and on early efforts to incorporate principles of physics in the modeling of ligand/receptor interactions, a few pioneering companies like Nimbus Therapeutics and Verseon Corp. are pushing the boundaries of computational drug design.

Kenneth M. Merz, PhD, director of Michigan State University’s Institute for Cyber-Enabled Research, and former head of Pharmacopeia Inc.’s Center for Informatics and Drug Discovery, says that the introduction...

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