The final straw for UK biotech ReNeuron Group PLC came in January 2003 when the group announced that its Phase II tricyclic anti-histamine ReN1869 for diabetic nephropathy didn't work. Shares fell by more than 60% to 3p (see Exhibit 1); they had already sunk from the 30p heights reached during mid-2002. Any investors not yet put off by the firm's core focus on an area that had long since lost its appeal—stem cells--certainly were following the clinical failure of these outlier projects.
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