Rough Guide To Targeted Protein Degradation

Drugging The Undruggable

By hijacking a process that cells use to keep themselves shipshape, targeted protein degradation has become a hot new area of drug development. In Vivo takes an in-depth look at the field ahead of a wave of data expected this year from early candidates that will give some insight into whether this strategy will truly open a new way to combat disease.

Ubiquitinin
Ligase enzyme tags protein for degradation by attaching a ubiquitin molecule • Source: Alamy

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