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CDI Market Snapshot: Microbiome Therapies Begin Descent On Landscape

 
• By David Wild

The recent US approval of Ferring’s microbiome-targeting Rebyota is set to change the treatment landscape for recurrent Clostridioides difficile infection and could be the proving ground for this class of agents. Rebyota is the first microbiome-targeting treatment to reach the market, but several promising candidates for the same indication are waiting in the wings.

Microbiome Treatments Come Of Age • Source: Shutterstock

Clostridioides difficile infection (CDI) is a billion-dollar problem that microbiome-targeted companies are keen to solve. CDI is arguably the lowest-hanging fruit for microbiome-focused companies as there is a clear rationale for treating a dysbiotic gastrointestinal tract through a microbial restoration approach, and there is a history of doing so effectively with fecal microbiota transplantation (FMT). What’s more, clinicians, patients and regulators are hungry for an equally effective but safer and more palatable alternative to FMT.

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