Can New Generation GLP-1s Overcome The Adherence Hurdle?

Novo Nordisk manufactures the two most prolific GLP-1 products available, both of which are injectable semaglutide products. The first, Ozempic, is indicated as an adjunct to diet and exercise to help improve glycemic control in adult patients with type 2 diabetes. It is also indicated to reduce the risk of major cardiovascular events in type 2 diabetics with an established cardiovascular disease. Meanwhile, Wegovy is indicated for weight management of obese or overweight adult patients with at least one weight-related condition, alongside a reduced calorie diet and increased physical activity. Patients taking Wegovy lost an average of 15.2% of their body weight in clinical trials.

A challenger has recently arrived to Novo Nordisk’s semaglutide supremacy in the form of Eli Lilly’s Mounjaro, which was approved by the US FDA with a diabetes indication last year. Mounjaro, likewise a weekly injection, induced weight loss of up to 15.7% in a recent clinical trial. (Also see "Lilly’s Mounjaro Shows Strong Sales And Data As Firm Eyes Obesity Market" - Scrip, 27 April, 2023.)