Finding Value Left On The Shelf: Karuna Case Study

PureTech’s gamble to take an older Eli Lilly drug off the shelf to redevelop in a new indication paid off. The company aims to replicate this 'Karuna model' in the near future.  

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PureTech Health plc's chief innovation and strategy officer, Eric Elenko, and president, Bharatt Chowrira, disclose details about the company's decision to develop a new schizophrenia therapy that could potentially alter the market – but can the model be repeated?

Founded by PureTech in 2009, Karuna Therapeutics, Inc. went public in 2019 and was acquired by Bristol Myers Squibb for $14bn in December 2023. KarXT (xanomeline-trospium), its lead asset,...

“We started with a complete blank sheet of paper, asking ‘What can we do to treat schizophrenia?’,” said Elenko. “At that point, there was a dearth of innovation [in schizophrenia...

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