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TB or not TB: Is Emergent‘s vaccine the solution?

 
• By Alexandra Shimmings

MVA85A, the leading investigational vaccine against TB, has failed to replicate early promising efficacy seen in adults in a new Phase IIb study in infants published this week in The Lancet. But despite the disappointment, experts say this should not spell the end for the product, and the study should provide useful pointers for planning other trials and vaccination strategies.

MVA85A, the leading investigational vaccine against TB, has failed to replicate early promising efficacy seen in adults in a new Phase IIb study in infants published this week in The Lancet. But despite the disappointment, experts say this should not spell the end for the product, and the study should provide useful pointers for planning other trials and vaccination strategies.

Currently, the only available vaccine against TB is still the live attenuated Bacille Calmette-Guerin or BCG vaccine, which was developed 90 years ago and has not been improved upon since....

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