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ProdiGene Inc.

 
• By Nancy Dvorin

ProdiGene Inc. was the first company to commercialize recombinant proteins from transgenic plants. It has used its head start to assemble a strong IP portfolio and form a number of strategic partnerships to advance its programs in proteins for biopharmaceutical and industrial applications. Using corn as its production vehicle, ProdiGene is close to hitting the market with an industrial enzyme, and will embark soon on clinical trials for edible human vaccines for e.coli and hepatitis B.

Being first has its advantages, admits Tony Laos, the president and CEO of ProdiGene Inc. ProdiGene became the first company to commercialize recombinant proteins from transgenic plants, collaborating with Sigma Chemical Co. to produce avidin and b-glucuronidase for diagnostic and research uses just one year after its formation in 1996. This early start has enabled ProdiGene to build a strong intellectual property portfolio and form a number of strategic partnerships to advance its programs in proteins for biopharmaceutical and industrial applications.

Supply problems and safety concerns are driving interest in plant-derived proteins. The traditional method of therapeutic protein production—fermentation using bacterial...

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