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Exploiting Connections and Navigating Bumps Along the Brain-Gut Axis

 
• By Chris Morrison

The recent setback in SUI by Lilly's depression drug duloxetine may have implcations for a handful of biotech companies aiming to exploit their knowledge of the brain-gut axis to develop CNS drugs for IBS, OAB and other below-the-belt indications. Dynogen and Vela are two companies with promising products in the area.

The Food and Drug Administration's intimation to Eli Lilly & Co. in late January that the regulator wouldn't approve Lilly's serotonin and norepinephrine reuptake inhibitor (SNRI) duloxetine as a treatment for stress urinary incontinence (SUI) could be a setback for more than just Lilly and partner Boehringer Ingelheim GMBH . [See Deal]

The FDA move surprised observers, particularly considering the lack of existing pharmacotherapy for SUI and duloxetine's safety profile, which have...

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