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Exploiting Connections and Navigating Bumps Along the Brain-Gut Axis

 
• By Chris Morrison

The recent setback in SUI by Lilly's depression drug duloxetine may have implcations for a handful of biotech companies aiming to exploit their knowledge of the brain-gut axis to develop CNS drugs for IBS, OAB and other below-the-belt indications. Dynogen and Vela are two companies with promising products in the area.

The Food and Drug Administration's intimation to Eli Lilly & Co. in late January that the regulator wouldn't approve Lilly's serotonin and norepinephrine reuptake inhibitor (SNRI) duloxetine as a treatment for stress urinary incontinence (SUI) could be a setback for more than just Lilly and partner Boehringer Ingelheim GMBH . [See Deal]

The FDA move surprised observers, particularly considering the lack of existing pharmacotherapy for SUI and duloxetine's safety profile, which have...

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Boehringer Ingelheim Expects Two Key Approvals In Second Half Of 2025

 
• By Andrew McConaghie

The privately held German pharma firm is hoping to bring a new generation of pulmonary fibrosis and cancer drugs to market but their commercial success is not yet a certainty.

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Pointing to data that show a benefit in reducing viral load and the histological signs of the infection, Memo says its drug, potravitug, could become the first therapy to treat BK polyomavirus in kidney transplant recipients.

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Leo Looks To Grow In US After Hand Eczema Cream Approval

 
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More from R&D

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• By Jessica Merrill

Gefurulimab will give AstraZeneca a new option to compete against Argenx’s Vyvgart Hytrulo, which is available subcutaneously.

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Obesity Beyond GLP-1s: Amylins – The Next Frontier

 
• By Aakash Babu

In this series of articles, we look at different mechanisms of actions beyond GLP-1s that could determine the obesity drug landscape in the coming years. First on our list – amylin receptor agonists, which analysts expect to grow into a $50bn market opportunity.