Historically, the method for producing glycoconjugate vaccines has been lengthy and complex with low yields, requiring two separate fermentation runs and numerous purification steps, as well as a tedious chemical conjugation step. In contrast, GlycoVaxyn AG's vaccine conjugates are produced in recombinant E. coli using a single fermentation run that includes the conjugation process, and subsequent downstream purifications.
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The Phase IIb study failed its primary and a key secondary endpoint, but showed activity on another key secondary and an exploratory endpoint.
GSK is sticking to its guns on its forecasts for Blenrep and the firm’s total sales in 2031 despite concerns about the antibody-drug conjugate’s approvability in the US.
PTC plans to compete with BioMarin’s two phenylketonuria drugs with efficacy data showing strong reduction of phenylalanine and ability for patients to liberalize their diets.
The BRUIN CLL-314 trial was designed to show noninferiority, but the p-value indicated a favorable result for Jaypirca in both the pre-treated and intent-to-treat populations.
The highlights of recent comments and insights from industry executives on the key issues covered in Scrip.
Cipla’s partnered filgrastim biosimilar is expected to debut in the US in Q2 FY26 and the Indian firm expects an investment return ratio for its biosimilar engine “not too far” from that of a complex generic product amid an enabling regulatory environment.
Celltrion is set to acquire a US biologics manufacturing facility that will "eliminate" its US tariff risks and provide a ready-made production base for future expansion.
