Cancer Metabolism Approach Uncovers Drug Target, Biomarker

Scientists at Agios Pharmaceuticals have shown that a mutated metabolic enzyme common to many brain cancers acts like an oncogene, reversing the previously held belief that it was not involved in cancer-causing activity. They also linked the mutation, IDH1, to a potential predictive biomarker for glioma patients. Their work helps validate a drug discovery apporach based on the study of proliferating cancer cell metabolism.