300 North 5th Avenue
Suite 150
Phrixus Pharmaceuticals Inc. aims to repurpose a compound that may be able to boost the blood-pumping capacity of damaged hearts. Carmeseal was originally developed in the 1950s by BASF as a surfactant called poloxamer-188. If results seen in several animal cardiovascular models can be reproduced in humans, Phrixus’ compound could become an emergency room treatment for acute decompensated heart failure.
300 North 5th Avenue
Suite 150
Reimbursement rules are disincentivizing innovation, according to Vas Narasimhan.
Recent moves in the industry include changes at the top at Ascentage Pharma, Inventiva and Brenig Therapeutics, plus five companies get new CFOs.
As AI-driven firms like Insilico, big pharma like J&J, Amgen, GSK and AstraZeneca and Chinese and Indian firms like BeOne and Dr. Reddy’s respectively advance PRMT5 inhibitor candidates, what’s driving interest, what could lead to the first global approval and what are the challenges ahead?