One of the key ways pathogens survive in patients receiving drug therapy for infection is by physically ridding their cells of the chemicals through molecular mechanisms known as efflux pumps. Given this role, biopharma researchers have been investigating compounds meant to act as efflux pump inhibitors and so increase the efficacy of existing antibacterial and other drugs. Count DesignMedix LLC. in that group. The start-up thinks its approach will eventually give rise to drugs that reverse resistance to fluoroquinolone antibiotics like Cipro, but the company is first working on a potential anti-malarial compound.
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CEO Paul Stoffels said gaining US clearance for an IND for its novel CAR-T product was demanding, but now opens up a pathway towards a pivotal study starting in 2025.
A final rejection of Leqembi could also spell the same fate for Lilly’s rival drug but public outcry and demand for Alzheimer’s therapies might force the regulator’s hand
Updated Phase II results from petosemtamab have impressed ahead of ASCO, outshining Keytruda monotherapy and its bispecific rival from Bicara.
Zydus expects strong mirabegron sales in FY26 amid US litigation even as it builds a growth pillar in vaccines with a world-first, Gates Foundation-aided dual shigella-typhoid vaccine under development and others on the WHO prequalified list
The royalty revenue stream acquirer has around 40 products in its portfolio and expects to generate roughly $3bn this year. Head of R&D and investments Marshall Urist talked about the investment strategy at the RBC Healthcare Conference.
