When oncology biotech start-up Karyopharm Therapeutics Inc. began its search for Series A investors in the summer of 2010, the young company's founders expected to take the traditional route of assembling a venture capital syndicate, with one early-stage firm adopting the lead and soliciting others to fill out the round. Given Karoypharm's lofty goal of raising double-digit millions, the start-up anticipated a complicated and potentially arduous process that could take months.
But the biotech's team got wind of an interested party outside the familiar loop of VC firms on its list. Board member and advisor Ronald DePinho, MD, a professor of...
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