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IL-17: Pushing The Limits Of A Drug Target

 
• By Mark Ratner

A series of recent and anticipated events is drawing attention to interleukin-17 and related cytokines – a set of immunological drug targets of long-standing interest to large and small companies. The current crop of big-company candidates are biologics and may prove too harsh for all but the most severe immunological conditions, leaving room for start-ups developing small molecules.

A series of recent and anticipated events is drawing attention to interleukin-17 (IL-17) and related cytokines – a set of immunological drug targets of long-standing interest to large and small companies. Novartis AG plans to file for approval this year for its anti-IL-17A antibody, secukinumab, in psoriasis. To complement that biologic, in August, the Swiss pharma also in-licensed Ensemble Therapeutics Corp.’s lead development program of orally available drug candidates against IL-17. [See Deal] And that same week, a paper in Nature Medicine from Roche’s Genentech Inc. showed that targeting IL-17 could mitigate tumor resistance to VEGF (anti-angiogenic) therapy, potentially extending the therapeutic modality to cancer.

For more than a decade, Big Pharma has been investing in IL-17-oriented programs aimed at a range of inflammatory and...

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