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Regeneron Emphasizes Pipeline Promise As Eylea Pricing Pressure Builds

 
• By Mandy Jackson

Regeneron Pharmaceuticals Inc. executives emphasized the blockbuster potential of product candidates in the company's late-stage research and development pipeline on Aug. 4, while noting that the top-selling biologic Eylea (aflibercept) is facing increased reimbursement and competitive pressures.

DNA

If two forthcoming US approval decisions go Regeneron Pharmaceuticals Inc.'s way – for the rheumatoid arthritis therapy sarilumab in October and the atopic dermatitis treatment dupilumab in the first half of 2017 – those products could offset a slowdown in Eylea's sales growth. The company doesn't expect a near-term or immediate decline, but executives noted that it was important to discuss challenges in the marketplace for vascular endothelial growth factor (VEGF) inhibitors that treat wet age-related macular degeneration (AMD) and other eye diseases.

Eylea "is one of our most important approved products and continues to grow well globally. Eylea is now at an annual global net sales run rate that exceeds $5bn," President...

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