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The NASH Pipeline: Replete With Targets And New Compounds

 
• By John Davis

The numerous different targets of investigational drugs for the treatment of NASH suggest the jury is still out on which mechanism of action is most likely to prove effective against the condition. Ireland’s Afimmune is the latest company wanting to advance an investigational drug for the disorder into late-stage clinical studies.

Liver anatomy
The anatomy of a liver • Source: Shutterstock

Many targets and drugs are being evaluated for the treatment of non-alcoholic steatohepatitis (NASH), a form of non-alcoholic fatty liver disease (NAFLD), but no one really knows which will turn out best for patients.

There is even a possibility researchers could turn to combinations of drugs with different mechanisms of action in order to produce an effective therapy, like hepatologists have done with another...

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