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Alnylam Ends Revusiran In Phase III, But Was Failure Due To Safety Or Efficacy?

 
• By Mandy Jackson

Alnylam’s stock fell more than 40% in after-hours trading following the decision to end development of revusiran based on an imbalance of deaths in the Phase III ENDEAVOR clinical trial, but executives see no read-through to the rest of the company’s RNAi platform.

Alnylam Pharmaceuticals Inc. offered few details on Oct. 5 about why deaths in the revusiran arm of the Phase III ENDEAVOR clinical trial were more frequent than in the placebo arm, and it’s unclear whether the failed drug’s problems were tied to efficacy, safety or both.

Alnylam fell 41.6% in after-hours trading to $41.04 per share after the company said it discontinued development of revusiran – its most advanced drug candidate – based on an imbalance of deaths in ENDEAVOR, which enrolled 206 patients with hereditary ATTR amyloidosis with cardiomyopathy (hATTR-CM)

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