Juno Stresses Differences Between Its CAR-Ts As JCAR015 Trial Put On Hold Again

Juno stressed structural differences, safety record and potential of its JCAR017 CAR-T therapy during a Nov. 23 call about the disappointing hold on its ROCKET ALL study for JCAR015 – the second clinical hold for the company’s most advanced development program.

Juno Therapeutics Inc. is stressing the structural differences between the chimeric antigen receptor T-cell therapies in its pipeline after two fatalities caused it to put the brakes on a study of JCAR015 in adult acute lymphoblastic leukemia.

Juno announced the voluntary hold on the Phase II ROCKET clinical trial in relapsed and refractory ALL on Nov. 23, noting that two patients died from cerebral edema

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