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Lynparza's Wider Prospects Boosted By Late-Stage Breast Cancer Study

 
• By Sten Stovall

Hopes for wider use of AstraZeneca Lynparza (olaparib) were boosted by Phase III data showing improved survival rates in patients with a certain type of breast cancer who used the PARP inhibitor compared with chemotherapy alone.

Breast Cancer ribbon

News that Lynparza (olaparib) works better than standard of care chemotherapy in treating a group of patients with HER2-negative metastatic breast cancer harboring germline BRCA1 or BRCA2 mutations has lifted hopes for the first-in-class drug – which is already been approved in the US for ovarian cancer – as well as for AstraZeneca PLC's overall DNA Damage Repair portfolio.

AstraZeneca announced Feb. 17 that Lynparza showed a statistically significant and clinically meaningful improvement in progression-free survival in patients with...

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Pfizer/Astellas’s Padcev Scores First Big Win In Bladder Cancer Study

 
• By Alaric DeArment

The drug, combined with Merck’s Keytruda, was successful among certain chemotherapy-ineligible MIBC patients, with another Phase III readout expected by March 2026.