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Safety Is Key As Celgene's Ozanimod Succeeds In First Pivotal MS Test

 
• By Mandy Jackson

Celgene's ozanimod successfully cleared its first Phase III hurdle in multiple sclerosis, but safety will be the S1P receptor modulator's differentiating factor in results presented later this year, with additional value coming from ulcerative colitis and Crohn's disease in the coming years.

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Both doses of Celgene Corp.'s ozanimod tested in the Phase III SUNBEAM clinical trial significantly beat the multiple sclerosis standard of care interferon on three different measures of efficacy, but safety may be the most important differentiator for the closely-watched drug.

Investors are keeping their eyes on Celgene's sphingosine-1 phosphate (S1P) receptor modulator, because it has the potential to be a blockbuster product outside of the company's hematology franchise, further diversifying revenue beyond the multiple myeloma backbone therapy Revlimid (lenalidomide) and giving its immunology and inflammation franchise a significant boost. That's why Celgene's stock gained 2

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