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OncoSec Pushes IL-12 Approach Forward In PD-1 Melanoma Failures

 
• By Emily Hayes

Company plans to pursue accelerated approval based on a single-arm registrational study of PD-1 failures, after reporting positive results from a Phase II study at the ASCO-SITC meeting.

OncoSec antibody
• Source: OncoSec

OncoSec Medical Inc. says that its approach for delivering the anticancer protein interleukin-12 directly to tumors is likely to work in combination with PD-1 inhibition in melanoma patients who failed a PD-1 inhibitor, based on results from a small, single-arm Phase II study. It is now planning a registrational trial in PD-1 failures.

OncoSec's proprietary ImmunoPulse platform delivers DNA-based therapeutics directly into tumors, eliciting a local but also a systemic approach, according to the company. Its lead "electroimmunotherapy" candidate is a DNA plasmid...

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• By Andrew McConaghie

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The information flow in the months before the approval of GSK’s Nucala in COPD provides an interesting case study, and brings to mind the cautionary tale of Alnylam’s Onpattro.

ASCO: J&J Banks On T-Cell Engager’s Safety In Prostate Cancer

 
• By Andrew McConaghie

The company highlighted the KLK2-targeting agent’s safety at ASCO but it may have to rely on combinations to make pasritamig competitive.

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ASCO: Regeneron Looks To Become Bigger Immuno-Oncology Player

 
• By Alaric DeArment

The drugmaker presented oral abstracts at the meeting for Libtayo in adjuvant cutaneous squamous-cell carcinoma and linvoseltamab in multiple myeloma.

ASCO: Lupin Presents Early Data On PRMT5 Inhibitor

 
• By Vibha Ravi

ASCO sees the debut of Lupin’s PRMT5 inhibitor candidate LRNP7457, currently in Phase I studies in India. While no drug with this mechanism of action has been approved anywhere so far, several candidates are in clinical trials.

Vera’s Atacicept Sets A New Efficacy Bar With Phase III Results In IgAN

 
• By Mandy Jackson

Vera is the first company to report Phase III data for a dual inhibitor of APRIL and BAFF in IgA nephropathy. Atacicept provided a 42% placebo-adjusted reduction in proteinuria.