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Will Ultragenyx/Kyowa Hypophosphatemia Data Support Uptake?

 
• By Mandy Jackson

Ultragenyx and partner Kyowa Hakko Kirin said burosumab (KRN23) met the primary endpoint regarding phosphate levels in a Phase III study that enrolled adult X-linked hypophosphatemia patients, but small effects on two out of three secondary endpoints could impact the product's use.

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Burosumab (KRN23) from Ultragenyx Pharmaceutical Inc. and Kyowa Hakko Kirin Co. Ltd. met the primary endpoint of an increase in serum phosphorous levels in a Phase III clinical trial testing the biologic in adults with X-linked hypophosphatemia (XLH), but the limited effect on certain secondary endpoints could reduce the product candidate's use in the rare bone-destroying disease.

Ultragenyx believes that burosumab's effects on three measures that impact XLH patients' quality of life will improve beyond the 24-week...

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