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Much Anticipated JULIET Data Show Novartis Playing Catch-Up On CAR-T Manufacturing

 
• By Mandy Jackson

Novartis reported positive early results for its lead CAR-T candidate CTL019 in DLBCL that appear to be consistent with Kite's competing therapy in the same indication, but the data show the Swiss big pharma ran into manufacturing issues that weren't resolved until later in the JULIET study.

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Novartis AG had some explaining to do on June 7 regarding the company's lead chimeric antigen receptor T cell (CAR-T) therapy, because an early look at CTL019 in diffuse large B cell lymphoma (DLBCL) showed efficacy comparable to Kite Pharma Inc.'s axicabtagene ciloleucel, but nine patients enrolled in the Phase II JULIET clinical trial were never treated due to manufacturing issues.

Novartis explained after the interim data for CTL019 (tisagenlecleucel) in DLBCL became available – the results will be presented on...

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In Brief: Starton Moves Low-Dose Lenalidomide To Phase IIa For Multiple Myeloma

 
• By Sushmita Panda

Study to add to safety and tolerability data for infused formulation and may help identify optimal dose for future pivotal trial.

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• By Andrew McConaghie

The company has established the efficacy of its biologic Saphenlo in systemic lupus erythematosus but is now investing across modalities to stay ahead of rivals.

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Sanofi Revels In More Positive Rilzabrutinib Data

 
• By Kevin Grogan

The oral BTK inhibitor impresses in a Phase II trial for IgG4-related disease.

Is Zydus’s Agenus Deal Opportunistic Or Strategic?

 
• By Vibha Ravi

Will Zydus’s acquisition and licensing deal with Agenus turn out to be a strategic move towards building an oncology portfolio or an opportunistic one driven by a venture capital mindset?

How AstraZeneca Aims To Stay Ahead In Lupus As New Competition Looms

 
• By Andrew McConaghie

The company has established the efficacy of its biologic Saphenlo in systemic lupus erythematosus but is now investing across modalities to stay ahead of rivals.