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Immuno-Oncology Outlook: Looking For Brain Cancer Options

 
• By Lucie Ellis-Taitt

Scrip analyses the potential of "hot" immunotherapy mechanisms, such as PD-1 inhibitors and CAR-T therapies, in various stages of clinical development for glioblastoma.

Thinker
Will immunotherapy combinations connect the dots to produce better outcomes in brain cancer? • Source: Shutterstock

Immunotherapy has quickly become a standard treatment option for patients with a number of tumor types, such as lung, bladder and kidney cancers, and the reach of immuno-oncology is spreading. But none of the current checkpoint inhibitors have proven effective in treating glioblastoma, a deadly form of cancer with few current treatment options and a poor survival rate.

Immuno-Oncology Outlook Series

The second in Scrip's series on immunotherapy expanding into new cancer types.

To read about the latest avenues for IO in renal cell cancer, see:

Immuno-Oncology Outlook: Pfizer's Inlyta Fits Well In Combos For Kidney Cancer

A number of companies will report clinical trial updates next year for their respective IO approaches to treating brain cancers....

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More from Immuno-oncology

BMS’s Breyanzi Stands To Further Expand Broad Lymphoma Coverage

 
• By Alaric DeArment

The drugmaker presented data at a lymphoma meeting showing strong efficacy for the CAR-T in marginal zone lymphoma, the second most common indolent lymphoma.

Henlius CEO Details PD-L1 ADC’s Path To 1L Mono/Combo Therapy

 
• By Dexter Jie Yan

Henlius is investigating the optimum dose for its PD-L1-targeting antibody-drug conjugate HLX43 to support potential first-line use, its CEO explains to Scrip.

Is Zydus’s Agenus Deal Opportunistic Or Strategic?

 
• By Vibha Ravi

Will Zydus’s acquisition and licensing deal with Agenus turn out to be a strategic move towards building an oncology portfolio or an opportunistic one driven by a venture capital mindset?

ASCO: Kite’s Glioblastoma CAR-T Highlights Solid Tumor Progress

 
• By Alaric DeArment

The company presented Phase I data for CART-EGFR-IL13Rα2, showing patient responses in the notoriously hard-to-treat and deadly brain cancer.

More from Anticancer

Quick Listen: Scrip’s Five Must-Know Things

 
• By Ian Haydock

In this week's episode: breaking down big pharma’s executive pay; US vaccine panel upheaval; Merck’s RSV approval; MFN and Japan; and the future of Pfizer and Arvinas’s partnership.

UroGen Gets A First-Ever Bladder Cancer Approval Despite US FDA AdComm ‘No’ Vote

 
• By Joseph Haas

UroGen’s Zusduri was approved despite an advisory committee vote recommending against it in May. It is the first approved drug for a type of recurring bladder cancer.

In Brief: Starton Moves Low-Dose Lenalidomide To Phase IIa For Multiple Myeloma

 
• By Sushmita Panda

Study to add to safety and tolerability data for infused formulation and may help identify optimal dose for future pivotal trial.