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MYSTIC Misses: Devastation For AstraZeneca As Imfinzi Fails PFS Endpoint In NSCLC

 
• By Lucie Ellis-Taitt

Topline Phase III data for AstraZeneca's PD-L1 inhibitor Imfinzi in NSCLC have overshadowed the group's second quarter earnings – but not in a good way. Positive Tagrisso data from the Phase III FLAURA trial reported at the same time were not enough to stem the stock bleed.

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AstraZeneca's Imfinzi misses PFS target in MYSTIC trial • Source: Shutterstock

AstraZeneca PLC's PD-L1 inhibitor, Imfinzi (durvalumab), a drug expected to act as the big pharma's backbone drug across its cancer immunotherapy portfolio, has failed to meet primary progression free survival (PFS) endpoints in the Phase III MYSTIC trial in non-small cell lung cancer.

In the Phase III study Imfinzi, a program death-ligand 1 inhibitor, in combination with tremelimumab failed to improve PFS compared...

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Genmab/AbbVie’s Epkinly Likely To See Label Expansion After Phase III Win

 
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Aurigene Oncology CEO On Biotech Valuations, CAR-Ts And Reimbursement Models

 
• By Anju Ghangurde

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Allogene Sticks With Standard Lymphodepletion In CAR-T Trial After Patient Death

 
• By Alaric DeArment

The company said it will no longer use ALLO-647 after a patient developed a fatal adenovirus infection, and it will pursue further development of its Dagger technology to minimize or eliminate the need for lymphodepletion.

AstraZeneca’s Tagrisso Mountain Grows, But The Climb Will Be Challenging

 
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The UK major continues to post promising data readouts that further emphasize the safety and efficacy of its blockbuster lung cancer drug, but competition from J&J's Rybrevant is ramping up, and capable challengers are emerging.

More from Anticancer

Cardiff Pushes Towards Colorectal Cancer Phase III As Funding Questions Loom

 
• By Manas Mishra

Cardiff Oncology is open to going it alone, a partnership and even an exit as the San Diego, CA-based firm tries to push its PLK1 inhibitor through late-stage development.

Allogene Sticks With Standard Lymphodepletion In CAR-T Trial After Patient Death

 
• By Alaric DeArment

The company said it will no longer use ALLO-647 after a patient developed a fatal adenovirus infection, and it will pursue further development of its Dagger technology to minimize or eliminate the need for lymphodepletion.

BioNTech Outlines Development Plan For PD-L1xVEGF-Targeting BNT-327

 
• By Jessica Merrill

The company, with partner Bristol Myers Squibb, has a three-wave development strategy for BNT-327: “establish, combine, broaden.”