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Mateon's CA4P Disappoints At Second Interim Analysis, More Data Awaited

 
• By John Davis

A third interim analysis, in September, may clarify whether Mateon’s vascular disrupting agent is likely to be therapeutically useful as a new class of agents for ovarian cancer.

Ovarian cancer
Ovarian cancer cells under the microscope • Source: Shutterstock

Early data from the Phase II/III FOCUS study found that Mateon Therapeutics Inc.’s CA4P (fosbretabulin) had a non-significant effect on progression-free survival (PFS) in patients with platinum-resistant ovarian cancer, and the number of partial responses were lower in the treated arm compared with the control arm of the study.

Company executives were not discouraged by the results, however

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