Merck Calls It Quits On Anacetrapib

12 Oct 2017

• By Mary Jo Laffler and Emily Hayes

Despite the success in the REVEAL outcomes trial for the cholesteryl ester transfer protein (CETP) inhibitor, Merck will not submit the cholesterol therapy for regulatory approval.

Merck & Co. Inc. is making the prudent choice in opting not to pursue regulatory approval for the CETP inhibitor anacetrapib, avoiding the commercial quagmire of the cholesterol market that has hindered uptake of the PCSK9 inhibitor class.

"The decision follows a thorough review of the clinical profile of anacetrapib, including discussions with external experts," the firm said in its Oct. 11 announcement.

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

Start your 7-day free trial
Explore trusted news, analysis, and insights
Access comprehensive global coverage
Enjoy instant access – no credit card required

Start Free Trial

Already a subscriber?

In Brief: Tourmaline Reports Positive Topline Phase II Results for Pacibekitug In CKD

21 May 2025

• By Sushmita Panda

Based on first positive results for any quarterly IL-6 inhibitor, company plans to initiate Phase III cardiovascular outcomes trial.

In Brief: Essence Raises Ionis Tryngolza Hypertriglyceridemia Filing Hopes

20 May 2025

• By Sushmita Panda

Tryngolza has met endpoints in a moderate hypertriglyceridemia trial. Positive results in severe disease in Q3 could allow for a filing for a broader patient population than its currently approved indication of familial chylomicronemia syndrome.