Albireo Making Headway In Rare Pediatric Liver Diseases With IBAT Inhibition

Biotech hopes to launch a Phase III trial in the rare disorder PFIC before year’s end. It thinks its therapy could offer similar benefits to surgery in reducing pruritus and improving liver parameters.

Scientist

Albireo Pharma Inc. is hoping to initiate a Phase III study for its lead candidate, the selective ileal bile acid transporter (IBAT) inhibitor A4250, in the rare genetic disease progressive familial intrahepatic cholestasis (PFIC) by the end of the year.

At the American Association for the Study of Liver Diseases meeting Oct

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