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Roche Powers Forward With First-Line Tecentriq In Advanced NSCLC

 
• By John Davis

The actual data on the clinically meaningful effect on PFS of the triple combination of Tecentriq, Avastin and chemotherapy on previously untreated advanced NSCLC patients in the IMpower150 study have now been presented at a scientific meeting, and suggest that Roche could be a significant competitor in the large NSCLC market in the not too distant future.

Lungs
• Source: Shutterstock

Roche's PD-L1 inhibitor Tecentriq (atezolizumab) was associated with a 38% reduction in the risk of disease worsening or death when used as part of a chemotherapy regimen for previously untreated advanced non-squamous non-small cell lung cancer in the IMpower150 study, the company announced on Dec. 7. This puts a concrete figure on last month's announcement that the Tecentriq combination had provided a statistically significant and clinically meaningful reduction in progression-free survival (PFS).

The IMpower150 study is the "first positive Phase III combination trial showing a cancer immunotherapy reduced the risk of worsening...

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