1. Scrip
  2. >>Therapy Areas
  3. >>Anticancer
  4. >>Immuno-oncology

Merck's Keytruda Enjoys Clean Sweep In Lung Cancer, At Bristol's Expense

 
• By Emily Hayes

Merck came out ahead in the immuno-oncology combination showdown at AACR, with a strong overall survival benefit for Keytruda/chemo in the Phase III KEYNOTE-189 study in first-line NSCLC. The data were seen as practice-changing, but Bristol's CheckMate-227 trial of Opdivo/Yervoy failed to impress in the same way.

Instagram style filter silhouette of a successful woman or girl arms raised celebrating at sunrise or sunset in front of the New York City Skyline

Merck & Co. Inc.'s PD-1 inhibitor Keytruda has emerged as the clear winner in non-squamous non-small cell lung cancer (NSCLC), with consistent and striking survival data for the combination of the drug with chemotherapy in the Phase III KEYNOTE-189 study, leaving an uncertain future for Bristol-Myers Squibb Co.'s competing Opdivo/Yervoy combination.

On April 16, the American Association for Cancer Research (AACR) meeting featured full data from landmark studies in first-line metastatic NSCLC. Merck's KEYNOTE-189 study compared Keytruda (pembrolizumab) with doublet chemotherapy – Eli Lilly & Co.'s Alimta (pemetrexed) and cisplatin or carboplatin vs

Read the full article – start your free trial today!

Join thousands of industry professionals who rely on Scrip for daily insights

  • Start your 7-day free trial
  • Explore trusted news, analysis, and insights
  • Access comprehensive global coverage
  • Enjoy instant access – no credit card required
Start Free Trial

Already a subscriber?

More from Immuno-oncology

More from Anticancer

GSK Chief Optimistic About BD Despite Volatile Environment

 
• By Kevin Grogan

Emma Walmsley tells Scrip that the "biotech market is under a certain degree of pressure," so reasonably priced deals are available.

CSPC’s Global-First Monospecific ADC Promising In Advanced NSCLC

 
• By Xu Hu

CSPC’s SYS6010, the first monospecific EGFR-targeting antibody-drug conjugate in the clinic for advanced NSCLC, has shown Phase I promise, but could face close competition with another China-originated bispecific.

AstraZeneca’s Truqap Trips Up In Prostate Cancer Study

 
• By Kevin Grogan

The AKT inhibitor proves ineffective for metastatic castration-resistant disease in a Phase III trial.