AstraZeneca PLC's ARCTIC study of its PD-L1 inhibitor/CTLA4 combination of Infimzi (durvalumab) and tremelimumab has failed to produce either a progression-free or survival benefit when used in the late-stage treatment of advanced non-small cell lung cancer (NSCLC) patients, initial data show.
ARCTIC Chill Descends On AstraZeneca's Imfinzi/Treme Combo In NSCLC
Failure of the ARCTIC study was considered likely and will do little to dent Imfinzi's overall sales prospects but cools sentiment on the CTLA4 inhibitor tremelimumab.
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