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ARCTIC Chill Descends On AstraZeneca's Imfinzi/Treme Combo In NSCLC

 
• By Alexandra Shimmings

Failure of the ARCTIC study was considered likely and will do little to dent Imfinzi's overall sales prospects but cools sentiment on the CTLA4 inhibitor tremelimumab.

Wind an clouds over the frozen snow in Lapland, Sweden.
Chill Over Tremelimumab In NSCLC

AstraZeneca PLC's ARCTIC study of its PD-L1 inhibitor/CTLA4 combination of Infimzi (durvalumab) and tremelimumab has failed to produce either a progression-free or survival benefit when used in the late-stage treatment of advanced non-small cell lung cancer (NSCLC) patients, initial data show.

The result was not unexpected following the initial disappointing PFS data for the combination from MYSTIC in first-line metastatic NSCLC...

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Pipeline Watch: Seven Approvals And Five Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.

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Xenon Nears Phase III Readout For Potential Epilepsy And Depression Blockbuster

 
• By Andrew McConaghie

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Post-GLP-1 Patients Are Significant Opportunity, But Response Sees More

 
• By Alaric DeArment

The company will move ahead in testing RDX-002 among overweight and obese patients coming off GLP-1s, but the CEO said antipsychotic-induced weight gain could represent a multibillion-dollar market.

Xenon Nears Phase III Readout For Potential Epilepsy And Depression Blockbuster

 
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Another Day Another Win For Novartis’s Ianalumab – This Time In ITP

 
• By Aakash Babu

The Swiss drugmaker’s BAFF-R inhibitor and ADCC-mediated B-cell depletor candidate has chalked up another win in late-stage development, further strengthening its pipeline-in-a-product bid.