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ARCTIC Chill Descends On AstraZeneca's Imfinzi/Treme Combo In NSCLC

 
• By Alexandra Shimmings

Failure of the ARCTIC study was considered likely and will do little to dent Imfinzi's overall sales prospects but cools sentiment on the CTLA4 inhibitor tremelimumab.

Wind an clouds over the frozen snow in Lapland, Sweden.
Chill Over Tremelimumab In NSCLC

AstraZeneca PLC's ARCTIC study of its PD-L1 inhibitor/CTLA4 combination of Infimzi (durvalumab) and tremelimumab has failed to produce either a progression-free or survival benefit when used in the late-stage treatment of advanced non-small cell lung cancer (NSCLC) patients, initial data show.

The result was not unexpected following the initial disappointing PFS data for the combination from MYSTIC in first-line metastatic NSCLC...

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Genentech Gets Columvi Complete Response Following ODAC’s No

 
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Actuate Is Looking For A Buyer To Advance Pancreatic Cancer Candidate

 
• By Jessica Merrill

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Actuate Is Looking For A Buyer To Advance Pancreatic Cancer Candidate

 
• By Jessica Merrill

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In Brief: Kezar Plots Lupus Revival For Zetomipzomib As FDA Lifts Hold On Hepatitis Trial

 
• By Manas Mishra

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• By Andrew McConaghie

Anselamimab was expected to complement Alexion's portfolio of amyloid therapies, but regulators will have to be convinced of its benefits to a patient subgroup in the CARES trial.