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Lonsurf Hits Phase III OS Target In Gastric Cancer Study

 
• By John Davis

An improvement in overall survival seen in the Phase III TAGS study and a unique mechanism of action augurs well for Taiho/Servier's Lonsurf gaining gastric cancer as an additional indication, but future competitive pressures are likely to be intense in this therapeutic sector.  

Helicobacter pylori
H pylori infection may precede the development of stomach cancer • Source: Shutterstock

French multinational Servier SA, may have moved a step closer to realizing its ambitions in oncology with positive top-line results emerging from the pivotal Phase III TAGS study, that is evaluating the oral anticancer therapy, Lonsurf (trifluridine plus tipiracil), in patients with gastric cancer. But research into better therapies for gastric cancer is intense, so future success is not a foregone conclusion.

Servier and the Otsuka subsidiary, Taiho Pharmaceutical Co. Ltd., are collaborating on the further development of Lonsurf, currently marketed...

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