Bristol Engineers An Oral TYK2 Inhibitor With Biologic-Like Efficacy That Rivals JAK Safety

The company's first set of Phase II data for its oral, selective TYK2 inhibitor in psoriasis showed a consistent dose response as well as safety that could rival the related JAK inhibitor class. BMS-986165 already is in Phase III for psoriasis; it's in Phase II for lupus and Crohn's disease.

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Bristol-Myers Squibb Co. reported Phase II results in psoriasis for BMS-986165, a selective inhibitor of tyrosine kinase 2 (TYK2), that show what the company's TYK2 program development lead John Throup described as "biologic-like efficacy, but with a very safe profile."

The data published in the New England Journal of Medicine and presented at the European Academy of Dermatology and Venerology (EADV) Congress in Paris on Sept. 12 may position BMS-986165 to compete with Janus kinase (JAK) inhibitors, a related drug class that's shown efficacy in psoriasis, psoriatic arthritis and inflammatory bowel disease (IBD), but with safety risks that the Bristol-Myers drug may avoid

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