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Spectrum To Test Poziotinib's Potential As First Line Treatment Of Exon 20 Mutant NSCLC

 
• By Jung Won Shin

Spectrum is expanding a clinical trial with its novel, oral pan-HER inhibitor poziotinib into the first-line treatment of NSCLC with EGFR or HER2 exon 20 insertion mutations, which could provide a much-needed new option for these patients. The move also marks further positive development progress for the drug, which the US firm licensed in from Hanmi.

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Poziotinib trials expanded to first-line EGFR or HER2 Exon 20 mutant NSCLC • Source: Shutterstock

Spectrum Pharmaceuticals Inc. has initiated two new cohorts for first-line, locally advanced or metastatic non-small cell lung cancer (NSCLC) patients with EGFR or HER2 exon 20 insertion mutations in its current Phase II NSCLC clinical trial with poziotinib, and has dosed the first patient in the expanded patient population.

The poziotinib NSCLC clinical program for patients with EGFR or HER2 exon 20 mutations currently consists of a Phase II pivotal, Spectrum-sponsored, multi-center global study (ZENITH20) with active sites in the US and future centers planned in Canada and Europe, plus a

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