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Viking’s Liver Fat Reduction Data Portend A New Competitor In NASH

 
• By Joseph Haas

In a Phase II study, Viking’s VK2809, with the same mechanism as Madrigal’s MGL-3196, shows significant liver fat reduction in NAFLD patients, along with reduction in LDL cholesterol.

Yellow road sign with a blue sky and white clouds: clinical trial

Viking Therapeutics Inc. may have a heavy hitter on its hands if results from a small Phase II study of VK2809 stand up in larger studies – the novel, liver-selective thyroid receptor beta agonist yielded a 58% reduction in liver fat from baseline over 12 weeks, according to top-line data in patients with non-alcoholic fatty liver disease (NAFLD) reported Sept. 18. NAFLD is a precursor condition to non-alcoholic steatohepatitis (NASH).

VK2809 showed a statistically significant reduction in LDL cholesterol levels in the same study, suggesting both cardiovascular and hepatic health...

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