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AstraZeneca's PACIFIC Update Bolsters Imfinzi's Lead In Stage III Lung Cancer

 
• By Emily Hayes

Full PACIFIC data show strong overall survival benefit in all comers, though not in a post hoc analysis of those with low PD-L1 expression, about 20% of the population.

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Updated data from AstraZeneca PLC's pivotal PACIFIC study show a 32% overall survival benefit for Imfinzi in Stage III non-small cell lung cancer, a space where the PD-L1 inhibitor is already popular and the company has a monopoly. However, the trial results raise questions about whether a large subset of patients with low or no PD-L1 expression should be treated.

The Phase III PACIFIC study tested the immune checkpoint inhibitor Imfinzi (durvalumab) vs. placebo, randomized 2:1, after chemoradiation (CRT) therapy...

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