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Can Takeda's Alunbrig Take On Roche's Alecensa In First-Line ALK-Positive Lung Cancer?

 
• By Emily Hayes

Takeda's Phase III win over Pfizer's Xalkori leaves oncologists cheering, but hankering for a head-to-head study against Alecensa, which is becoming the standard of care in the US for first-line ALK+ NSCLC.

lung illustration

Takeda Pharmaceutical Co. Ltd.'s ALK inhibitor Alunbrig is now in position to challenge next-generation anaplastic lymphoma kinase (ALK) inhibitors in mutated non-small cell lung cancer (NSCLC) after pummeling Pfizer Inc.'s first-to-market Xalkori in the Phase III ALTA-1 study.

Alunbrig (brigatinib) received accelerated US FDA approval in April 2017 for use in ALK-positive NSLC after development of tolerance to Xalkori (crizotinib)

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Pipeline Watch: Six Approvals And Thirteen Phase III Readouts

Pipeline Watch is a weekly snapshot of selected late-stage clinical trial events and approvals announced by pharmaceutical and biotech companies at medical and industry conferences, in financial and company presentations, and in company releases and statements.

Viatris Will File ‘Fast-Acting’ Meloxicam For FDA Approval This Year

 
• By Joseph Haas

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CRISPR Therapeutics Unveils Promising Early In Vivo Cholesterol-Lowering Results

 
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Sanofi R&D Head’s Words Of Wisdom For Biotechs

 
• By Kevin Grogan

Houman Ashrafian tells delegates at Swiss Biotech Day that ‘literally only two things matter in our industry – target credentialing and differentiated pharmacology. The rest is execution.’

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First Win For AstraZeneca’s Enhertu In Early-Stage Breast Cancer Treatment

 
• By Andrew McConaghie

Already dominating in later lines of breast cancer treatment, Enhertu could now displace both chemotherapy combinations and Roche’s Kadcyla in early-stage HER2-positive patients.