Merck KGAA/Pfizer's Anti-PD-L1 Bavencio Loses An Opportunity In Ovarian Cancer

PD-1/L1 inhibitors are eagerly awaited in ovarian cancer, but the combination of Bavencio with chemotherapy doesn't work well in platinum-resistant disease.

Cancer in ovary of woman illustration

Merck KGAA and Pfizer Inc.'s Bavencio (avelumab) lost an opportunity to crack the ovarian cancer market early with the anti-PD-L1 checkpoint inhibitor's failure as monotherapy and in combination with chemotherapy in the Phase III JAVELIN Ovarian 200 study of tough-to-treat platinum-resistant or refractory disease.

The companies announced in a Nov

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