BMS SCLC Chances Dive After Opdivo, Yervoy Combo Flunks Checkmate-451

BMS's Phase III Checkmate-451 combo trial with Opdivo and Yervoy misses its endpoint for small cell lung cancer in overall survival, building on recent disappointment caused by the failure of Checkmate-331.

Lung cancer
Bristol-Myers Squibb's Checkmate-451 Tested Opdivo and Yervoy in Small cell Lung Cancer • Source: Shutterstock

Bristol-Myers Squibb Co.'s prospects in small cell lung cancer (SCLC) now look doubtful after the US group reported disappointing Phase III data from CheckMate-451 in which Opdivo (nivolumab) combined with Yervoy (ipilimumab) missed the primary endpoint of overall survival, analysts say.

The miss comes shortly after BMS's Phase III Checkmate-331 in relapsed small cell lung cancer using Opdivo failed to meet...

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