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AZ Lynparza Head Hopes 2020 Will See PARP Inhibitor Treating Pancreatic Cancer

 
• By Sten Stovall

AstraZeneca and Merck & Co hope Lynparza will soon have a third treatment indication after their PARP inhibitor became the first to demonstrate a benefit in germline BRCA-mutated metastatic pancreatic cancer, having hit targets in the Phase III POLO trial.

Pancreas
Lynparza Phase III POLO Trial Met Primary PFS Endpoint In Pancreatic Cancer • Source: Shutterstock

AstraZeneca PLC and Merck & Co. Inc. will soon initiate talks with regulators after their breast and ovarian cancer drug Lynparza  (olaparib) cut the risk of disease progression or death as a first-line maintenance treatment in germline BRCA-mutated metastatic pancreatic cancer. If all goes well the PARP inhibitor will have its third indication in by 2020, according to Greg Rossi, global medicines lead for Lynparza at AstraZeneca.

He was speaking to Scrip after Lynparza, which is currently being used as treatments for ovarian and breast cancer, showed itself in the Phase III POLO trial to be better at preventing gBRCAm

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