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Vertex Selects VX-445 For CF Triple Therapy Due To Safety/Tolerability

 
• By Joseph Haas

Already dominant in cystic fibrosis, Vertex hopes its triple regimen will address roughly 90% of the patient population. It also hopes the benefits of the triple will smooth EU reimbursement talks.

Cystic Fibrosis
Vertex develops and markets therapies addressing the underlying cause of CF

Vertex Pharmaceuticals Inc. has decided to use its next-generation CFTR corrector VX-445 as the third component of its triple therapy regimen for cystic fibrosis, choosing that compound over VX-659 mainly on considerations of safety and tolerability. The Boston-area firm now plans to file its triple regimen for US approval in the third quarter and for European approval in the fourth quarter.

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