Amyloidosis Drug Competitors Can Coexist While Growing The Market, Alnylam CEO Says

The recent US FDA approval of three drugs – Alnylam’s Onpattro, Ionis’ Tegsedi and Pfizer’s tafamidis – in transthyretin-mediated amyloidosis means more opportunities to increase education and improve diagnosis in this rare disease, Alnylam CEO John Maraganore tells Scrip.

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The high rate of undiagnosed ATTR patients provides ample opportunity to grow the market for this rare disease. • Source: Shutterstock

There is room for all three companies in the hereditary transthyretin-mediated amyloidosis (hATTR) space – Alnylam Pharmaceuticals Inc., Ionis Pharmaceuticals Inc. and Pfizer Inc. – to collectively grow the market rather than duking it out with each other for share in this rare disease setting, Alnylam CEO John Maraganore believes.

During the Biotechnology Innovation Organization’s annual meeting in Philadelphia, Maraganore talked to Scrip about how he sees competition playing out in the US hATTR market, where the majority of patients are undiagnosed, now that

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