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BMS' Bid For Opdivo In First-Line HCC Stymied

 
• By Joseph Haas

Top-line results from a Phase III study testing Opdivo versus Nexavar in first-line liver cancer fail to meet OS target. Bristol points to positive numerical trend, but the results are a setback in the indication.

Digital illustration of lung cancer cells in color background - Illustration
Opdivo is approved for second-line HCC therapy

Bristol-Myers Squibb Co. missed in its effort to show PD-1 inhibitor Opdivo could improve upon standard-of-care Nexavar in first-line hepatic cell carcinoma (HCC), leaving the pharma to look for a combination regimen with CTLA-4 inhibitor Yervoy in previously treated patients, as well as monotherapy in adjuvant care.

On a day of dual surprises for investors, BMS revealed that CheckMate-459 did not demonstrate a statistically significant benefit on overall survival (OS) compared to Bayer AG/Amgen Inc.’s...

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