Road Ahead Unclear For Polyphor’s Intravenous Murepavadin

The Swiss firm is still examining options for the iv formulation of its novel antibiotic murepavadin even after it closed its two Phase III studies on safety concerns.

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Polyphor Ltd. has decided to close the two Phase III trials of murepavadin iv for hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) that were put on a voluntary temporary hold in May, spelling the likely end for the program.

The Phase III trials – PRISM-MDR and PRISM-UDR – were evaluating murepavadin in patients with nosocomial pneumonia but a higher...

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