AstraZeneca PLC’s Imfinzi-tremelimumab combination has failed to improve overall survival in metastatic non-small cell lung cancer (NSCLC) patients, dealing another blow to the company’s push to establish its anti-CTLA4 antibody as part of the immuno-oncology treatment toolkit.
AstraZeneca’s Imfinzi-Treme Checkpoint Inhibitor Combination Fails Again In NSCLC
The Phase III NEPTUNE lung cancer trial found the combination of Imfinzi and tremelimumab was no better than chemotherapy at extending overall survival. After repeat setbacks, AstraZeneca is now running out of opportunities to show its dual checkpoint blockade is effective in NSCLC.
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