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InDex's Lead TLR9 Agonist Shows Promise In Ulcerative Colitis

 
• By John Davis

A Toll-like receptor-9 agonist under development by Sweden’s InDex Pharmaceuticals showed encouraging clinical responses in top-line results in patients with active ulcerative colitis not responding to other agents. Its novel mechanism of action and relatively benign side effect profile makes it a prime candidate to combine with biologic agents.  

Bowels
• Source: Shutterstock

A potential first-in-class Toll-like receptor 9 (TLR9) agonist, InDex Pharmaceuticals AB’s cobitolimod, has met its primary clinical remission endpoint in top-line results from a Phase IIb study, CONDUCT, in patients with active moderate to severe ulcerative colitis, giving a boost to the small Swedish company’s share price and promising a potential option for patients who do not respond to other therapies.

Cobitolimod could also be of particular interest for use in combination with other agents, according to InDex’s CEO, Peter Zerhouni,...

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