Updated results for Amgen Inc.'s AMG 510, its small molecule targeting the G12C mutation of the KRAS oncogene, that were presented at the European Society for Medical Oncology (ESMO) meeting on 28 September in Barcelona, Spain, showed limited efficacy in colorectal cancer (CRC) patients, but the company is optimistic that its drug can perform better than approved CRC therapies, particularly in combination with other agents.
Only one out of 12 colorectal cancer patients (8%) treated with 960mg of AMG 510 daily – the highest dose...