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Blow To AZ As FDA Rejects COPD Contender

 
• By Andrew McConaghie

Issued with a complete response letter from the FDA, the company says it will now submit newer data showing the combination's effects on exacerbations.  

AZCambridge_HQ
AstraZeneca's new respiratory franchise, like its HQ, is under construction • Source: AstraZeneca

AstraZeneca PLC’s goal of challenging GlaxoSmithKline PLC's lead in chronic obstructive pulmonary disease has been dealt a blow after the US Food and Drug Administration rejected its new triple therapy combination, PT010.

Also known as Breztri Aerosphere in Japan, where the drug was approved in June, the company has disclosed that the...

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Lyra Eyes US Filing For LYR-210 After Surprise ENLIGHTEN 2 Win

 
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• By Alaric DeArment

The company presented Phase I data for CART-EGFR-IL13Rα2, showing patient responses in the notoriously hard-to-treat and deadly brain cancer.

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Will Pfizer Walk Away From Arvinas After PROTAC Disappointment?

 
• By Andrew McConaghie

Arvinas and Pfizer have just filed the potential first-in-class protein degrader vepdegestrant, but its diminished commercial prospects after mixed Phase III data mean Pfizer could exit.